58980

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58980

Fluka

 

Isoniazid

purum, for fluorescence, ≥99.0% (NT)

Synonym:INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
CAS Number:54-85-3
Linear Formula:C6H7N3O
Molecular Weight:137.14
Beilstein Registry Number:119374
EC Number:200-214-6
MDL number:MFCD00006426

Description

ApplicationUsed for fluorescence detection in the high-performance liquid chromatography of olefinic 3-ketosteroids1
Biochem/physiol ActionsAntibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Properties

gradefor fluorescence
 purum
assay≥99.0% (NT)
fluorescenceλex 433 nm; λem 500 nm in methanol (after derivatization with progesterone and as complex with Al3+)
mp170-173 °C
 171-173 °C(lit.)

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXn
Risk Statements22-38
Safety Statements37
WGK Germany3
RTECSNS1751850

Related Products

Replaced byI3377, Isoniazid

References

Cited Reference1. R. Horikawa et al. J. Chromatogr. 168, 526, (1979)
referenceHuang, Y.S., et al. Hepatology 37, 924-930, (2003)
 Wen, X., et al. Eur. J. Clin. Pharmacol. 57, 799-804, (2002)
 Zand, R., et al. Clin. Pharmacol. Ther. 54, 142-149, (1993)
MerckMerck 13,5205
BeilsteinBeil. 22,V,2,219
 Aldrich MSDS 1, 1114:A / Corp MSDS 1 (1), 2026:C / FT-IR 1 (2), 798:B / FT-IR 2 (3), 3805:C / FT-NMR 1 (3), 341:A / IR-Spectra (3), 1346:G / IR-Spectra (2), 1172:H / NMR-Reference 2 (2), 676:D / RegBook 1 (2), 2551:C / Sax 6, 1643 / Sigma FT-IR 1 (1), 671:D / Structure Index 1, 403:B:2